Research overview

Transport in nanopores and nanofluidics

K. Chen, I. Jou, N. Ermann, M. Muthukumar, U. F. Keyser, N. A. W. Bell. Dynamics of driven polymer transport through a nanopore. Nature Physics 2021, 17, 1043-1049. 

N. A. W. Bell,# K. Chen,# S. Ghosal, M. Ricci, U. F. Keyser. Asymmetric dynamics of DNA entering and exiting a strongly confining nanopore. Nature Communications 2017, 8, 380. 

N. Ermann, N. Hanikel, V. Wang, K. Chen, N. E. Weckman, U. F. Keyser. Promoting single-file DNA translocations through nanopores using electro-osmotic flow. The Journal of Chemical Physics 2018, 149, 163311. 

K. Chen, N. A. W. Bell, J. Kong, Y. Tian, U. F. Keyser. Direction- and Salt-Dependent Ionic Current Signatures for DNA Sensing with Asymmetric Nanopores. Biophysical Journal 2017, 112, 674-682. 

Single-molecule sensing of 

DNA, RNA and proteins

S. E. Sandler, N. E. Weckman, S. Y. Akashaditya Das, K. Chen, R. Guitterez and U. F. Keyser. 

Sensing the DNA-mismatch tolerance of catalytically inactive Cas9 via barcoded DNA nanostructures in solid-state nanopores

Nature Biomedical Engineering 2023

F. Boskovic, J. Zhu, R. Tivony, A. Ohmann, K. Chen, M. Alawami, M. Đorđević, N. Ermann, J. P. Dias, M. Fairhead, M. Howarth, S. Baker, U. F. Keyser. 

Simultaneous identification of viruses and viral variants with programmable DNA nanobait

Nature Nanotechnology 2023, 18, 290-298.

K. Chen, F. Gularek, B. Liu, E. Weinhold, U. F. Keyser. Electrical DNA sequence mapping using oligodeoxynucleotide labels and nanopores. ACS Nano 2021, 15, 2679-2685. 

N. E. Weckman, N. Ermann, R. Gutierrez, K. Chen, J. Graham, A. Heron, U. F. Keyser. In Pushing the resolution of dCas9 barcodes for multiplexed DNA identification with nanopore sensors, 2019 IEEE Sensors, IEEE: 2019, pp 1-3. 

F. Boskovic, J. Zhu, K. Chen, U. F. Keyser. Monitoring G-Quadruplex Formation with DNA Carriers and Solid-State Nanopores. Nano Letters 2019, 19, 7996-8001.

N. E. Weckman, N. Ermann, R. Gutierrez, K. Chen, J. Graham, R. Tivony, A. Heron, U. F. Keyser Multiplexed DNA Identification Using Site Specific dCas9 Barcodes and Nanopore Sensing. ACS Sensors 2019, 4, 2065-2072. 

J. Kong, J. Zhu, K. Chen, U. F. Keyser. Specific Biosensing Using DNA Aptamers and Nanopores. Advanced Functional Materials 2018, 1807555. (IF: 18.808)

K. Chen, M. Juhasz, F. Gularek, E. Weinhold, Y. Tian, U. F. Keyser, N. A. W. Bell. Ionic Current-Based Mapping of Short Sequence Motifs in Single DNA Molecules Using Solid-State Nanopores. Nano Letters 2017, 17, 5199-5205.

DNA nanotechnology


K. Chen, J. Zhu, F. Bošković, U. F. Keyser. Nanopore-Based DNA Hard Drives for Rewritable and Secure Data Storage. Nano Letters 2020, 20, 3754-3760. 

K. Chen, J. Kong, J. Zhu, N. Ermann, P. Predki, U. F. Keyser. Digital Data Storage Using DNA Nanostructures and Solid-State Nanopores. Nano Letters 2019, 19, 1210-1215. 

F. Boskovic, A. Ohmann, U. F. Keyser, K. Chen. DNA structural barcode copying and random access. Small Structures 2021, 2000144 (Last corresponding author)

J. Zhu, J., N. Ermann, K. Chen, U. F. Keyser. Image Encoding Using Multi-Level DNA Barcodes with Nanopore Readout. Small, 2021, 2100711.